{"id":3668,"date":"2022-10-21T09:28:42","date_gmt":"2022-10-21T09:28:42","guid":{"rendered":"https:\/\/zbi-dev.cs.uni-saarland.de\/?page_id=3668"},"modified":"2023-04-13T01:33:35","modified_gmt":"2023-04-12T23:33:35","slug":"bioinformatics-prof-helms","status":"publish","type":"page","link":"https:\/\/zbi-dev.cs.uni-saarland.de\/en\/research-at-the-cbi\/research-groups\/bioinformatics-prof-helms\/","title":{"rendered":"Bioinformatics (Prof. Helms)"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"3668\" class=\"elementor elementor-3668\">\n\t\t\t\t\t\t<div class=\"elementor-inner\">\n\t\t\t\t<div class=\"elementor-section-wrap\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4c350f4 elementor-section-boxed elementor-section-gap-beside-yes elementor-section-height-default elementor-section-height-default elementor-section-column-vertical-align-stretch elementor-invisible\" data-id=\"4c350f4\" data-element_type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;unicampFadeInUp&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-extended\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f720a32\" data-id=\"f720a32\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e34116b elementor-widget elementor-widget-tm-heading\" data-id=\"e34116b\" data-element_type=\"widget\" data-widget_type=\"tm-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"tm-modern-heading\">\n\t\t\t\n\t\t\t\t\t<div class=\"heading-primary-wrap\">\n\t\t\t<h2 class=\"heading-primary elementor-heading-title\">About us<\/h2>\t\t<\/div>\n\t\t\n\t\t\t\t    <div class=\"heading-divider\"><\/div>\n\t    \n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c6093fa elementor-widget elementor-widget-spacer\" data-id=\"c6093fa\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.14.0 - 26-06-2023 *\/\n.elementor-column .elementor-spacer-inner{height:var(--spacer-size)}.e-con{--container-widget-width:100%}.e-con-inner>.elementor-widget-spacer,.e-con>.elementor-widget-spacer{width:var(--container-widget-width,var(--spacer-size));--align-self:var(--container-widget-align-self,initial);--flex-shrink:0}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container,.e-con-inner>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer,.e-con>.elementor-widget-spacer>.elementor-widget-container,.e-con>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer{height:100%}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer>.elementor-spacer-inner,.e-con>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer>.elementor-spacer-inner{height:var(--container-widget-height,var(--spacer-size))}<\/style>\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-885bdb5 elementor-section-boxed elementor-section-gap-beside-yes elementor-section-height-default elementor-section-height-default elementor-section-column-vertical-align-stretch\" data-id=\"885bdb5\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-extended\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-c35ee51\" data-id=\"c35ee51\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b5037df elementor-widget elementor-widget-text-editor\" data-id=\"b5037df\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.14.0 - 26-06-2023 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<p>The research group headed by Prof. Dr. Helms applies numerical simulations, as well as statistical methods to study biomolecular interactions and control loops in cells. Current topics of interest are the modeling of protein-protein contacts, as well as interactions between DNA and proteins, which both play a central role in the control of all major biological processes. Within the field of membrane bioinformatics, we are deriving structural and functional motifs from the protein sequences of integral membrane proteins. Of particular interest to us is to increase the understanding of specific molecular interactions in the context of large scale biological processes. This affords insights into the origin of diseases at the molecular level.<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9b1275d elementor-widget elementor-widget-spacer\" data-id=\"9b1275d\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f46263b elementor-widget elementor-widget-premium-addon-button\" data-id=\"f46263b\" data-element_type=\"widget\" data-widget_type=\"premium-addon-button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\r\n\r\n\t\t<a class=\"premium-button premium-button-none premium-btn-lg premium-button-none\" href=\"https:\/\/www-cbi.cs.uni-saarland.de\/\" target=\"_blank\">\r\n\t\t\t<div class=\"premium-button-text-icon-wrapper\">\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<i class=\"premium-svg-nodraw premium-drawable-icon icon icon-right-arrow\" aria-hidden=\"true\"><\/i>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span >\r\n\t\t\t\t\tTo the group's website\t\t\t\t<\/span>\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t<\/a>\r\n\r\n\r\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8e33bdc elementor-hidden-desktop elementor-widget elementor-widget-spacer\" data-id=\"8e33bdc\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-f181ab1\" data-id=\"f181ab1\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7d2fc40 elementor-widget elementor-widget-image\" data-id=\"7d2fc40\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.14.0 - 26-06-2023 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t<div class=\"elementor-image\">\n\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" loading=\"lazy\" width=\"945\" height=\"730\" src=\"https:\/\/zbi-dev.cs.uni-saarland.de\/wp-content\/uploads\/2023\/03\/E.-coli-AR-Network-e1680116598842.png\" class=\"attachment-full size-full wp-image-6181\" alt=\"\" srcset=\"https:\/\/zbi-dev.cs.uni-saarland.de\/wp-content\/uploads\/2023\/03\/E.-coli-AR-Network-e1680116598842.png 945w, https:\/\/zbi-dev.cs.uni-saarland.de\/wp-content\/uploads\/2023\/03\/E.-coli-AR-Network-e1680116598842-300x232.png 300w, https:\/\/zbi-dev.cs.uni-saarland.de\/wp-content\/uploads\/2023\/03\/E.-coli-AR-Network-e1680116598842-768x593.png 768w\" sizes=\"(max-width: 945px) 100vw, 945px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Section of a gene regulatory network of the bacterium E. coli with annotated mutations in antibiotic resistance genes.<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-96f7223 elementor-widget elementor-widget-spacer\" data-id=\"96f7223\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a3a45f9 elementor-section-boxed elementor-section-gap-beside-yes elementor-section-height-default elementor-section-height-default elementor-section-column-vertical-align-stretch elementor-invisible\" data-id=\"a3a45f9\" data-element_type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;unicampFadeInUp&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-extended\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8967305\" data-id=\"8967305\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8f4ceb4 elementor-widget elementor-widget-tm-heading\" data-id=\"8f4ceb4\" data-element_type=\"widget\" data-widget_type=\"tm-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"tm-modern-heading\">\n\t\t\t\n\t\t\t\t\t<div class=\"heading-primary-wrap\">\n\t\t\t<h2 class=\"heading-primary elementor-heading-title\">Head of the Group<\/h2>\t\t<\/div>\n\t\t\n\t\t\t\t    <div class=\"heading-divider\"><\/div>\n\t    \n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ae53ab5 elementor-widget elementor-widget-spacer\" data-id=\"ae53ab5\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-69a5289 elementor-section-boxed elementor-section-gap-beside-yes elementor-section-height-default elementor-section-height-default elementor-section-column-vertical-align-stretch\" data-id=\"69a5289\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-extended\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-e29b864\" data-id=\"e29b864\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fc719ae elementor-widget elementor-widget-image\" data-id=\"fc719ae\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-image\">\n\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" loading=\"lazy\" width=\"683\" height=\"600\" src=\"https:\/\/zbi-dev.cs.uni-saarland.de\/wp-content\/uploads\/2022\/10\/helms.jpg\" class=\"attachment-full size-full wp-image-3671\" alt=\"\" srcset=\"https:\/\/zbi-dev.cs.uni-saarland.de\/wp-content\/uploads\/2022\/10\/helms.jpg 683w, https:\/\/zbi-dev.cs.uni-saarland.de\/wp-content\/uploads\/2022\/10\/helms-300x264.jpg 300w, https:\/\/zbi-dev.cs.uni-saarland.de\/wp-content\/uploads\/2022\/10\/helms-600x527.jpg 600w\" sizes=\"(max-width: 683px) 100vw, 683px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-714eccd elementor-hidden-desktop elementor-widget elementor-widget-spacer\" data-id=\"714eccd\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-09a6cb0\" data-id=\"09a6cb0\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b912393 elementor-widget elementor-widget-tm-heading\" data-id=\"b912393\" data-element_type=\"widget\" data-widget_type=\"tm-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"tm-modern-heading\">\n\t\t\t\n\t\t\t\t\t<div class=\"heading-primary-wrap\">\n\t\t\t<h4 class=\"heading-primary elementor-heading-title\">Prof. Dr. Volkhard Helms<\/h4>\t\t<\/div>\n\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5ca2ce4 elementor-widget elementor-widget-text-editor\" data-id=\"5ca2ce4\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<p class=\"rtejustify\">Volkhard Helms has been Professor of Bioinformatics in the Center of Bioinformatics Saar since 2003 and is also a member of the CBI Saar Directorate. He studied physics in Freiburg and Munich and obtained his PhD at the European Molecular Biology Laboratory in Heidelberg in 1996. He then carried out post- doctoral work at the University of California, San Diego, and went on to lead a research group in theoretical biophysics at the Max Planck Institute of Biophysics in Frankfurt. In 2001 he was selected as an EMBO Young Investigator.<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e1332d6 elementor-widget elementor-widget-tp-blockquote\" data-id=\"e1332d6\" data-element_type=\"widget\" data-widget_type=\"tp-blockquote.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"pt-plus-text-block-wrapper\" ><div class=\"text_block_parallax\"><div class=\"plus_blockquote quote-style-1   none \" ><blockquote class=\"quote-text\"><span class=\"tp-bq-desc\"><p><em>\"Via the modelling of single biomolecular interactions and regulation processes the group desires to arrive at a comprehensive understanding of cell biological processes.\"<\/em><\/p><\/span><\/blockquote><\/div><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-540f61e elementor-section-boxed elementor-section-gap-beside-yes elementor-section-height-default elementor-section-height-default elementor-section-column-vertical-align-stretch elementor-invisible\" data-id=\"540f61e\" data-element_type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;unicampFadeInUp&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-extended\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-111db98\" data-id=\"111db98\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0e412e9 elementor-widget elementor-widget-spacer\" data-id=\"0e412e9\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c4d03bb elementor-widget elementor-widget-tm-heading\" data-id=\"c4d03bb\" data-element_type=\"widget\" data-widget_type=\"tm-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"tm-modern-heading\">\n\t\t\t\n\t\t\t\t\t<div class=\"heading-primary-wrap\">\n\t\t\t<h2 class=\"heading-primary elementor-heading-title\">Our Projects<\/h2>\t\t<\/div>\n\t\t\n\t\t\t\t    <div class=\"heading-divider\"><\/div>\n\t    \n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e5fa965 elementor-widget elementor-widget-spacer\" data-id=\"e5fa965\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-de363bf elementor-widget elementor-widget-tm-heading\" data-id=\"de363bf\" data-element_type=\"widget\" data-widget_type=\"tm-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"tm-modern-heading\">\n\t\t\t\n\t\t\t\t\t<div class=\"heading-primary-wrap\">\n\t\t\t<h4 class=\"heading-primary elementor-heading-title\">Functional assignment of transmembrane proteins<\/h4>\t\t<\/div>\n\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c5450bf elementor-widget elementor-widget-spacer\" data-id=\"c5450bf\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-8610833 elementor-section-boxed elementor-section-gap-beside-yes elementor-section-height-default elementor-section-height-default elementor-section-column-vertical-align-stretch\" data-id=\"8610833\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-extended\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-d8af6f3\" data-id=\"d8af6f3\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e5860f7 elementor-widget elementor-widget-text-editor\" data-id=\"e5860f7\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<p>About a quarter of all proteins is integrated into the cell membrane or into the membranes of cellular compartments. There, they mediate the transport of small molecules through the membrane, or transduct signals from messenger substances, which dock to the cell into its interior. We are particularly interested in elucidating the assignment of substrate molecules to their corresponding membrane transporters, because only little is known so far. For this purpose, we are developing new statistical methods, as well as a software environment to model a virtual cell membrane.<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-03830e7 elementor-hidden-desktop elementor-widget elementor-widget-spacer\" data-id=\"03830e7\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-6b7b2d1\" data-id=\"6b7b2d1\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d70cdd7 elementor-widget elementor-widget-image\" data-id=\"d70cdd7\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-image\">\n\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" loading=\"lazy\" width=\"745\" height=\"421\" src=\"https:\/\/zbi-dev.cs.uni-saarland.de\/wp-content\/uploads\/2023\/03\/Protein-Protein-Interaktion-an-einer-Membranschicht.jpg\" class=\"attachment-full size-full wp-image-6178\" alt=\"\" srcset=\"https:\/\/zbi-dev.cs.uni-saarland.de\/wp-content\/uploads\/2023\/03\/Protein-Protein-Interaktion-an-einer-Membranschicht.jpg 745w, https:\/\/zbi-dev.cs.uni-saarland.de\/wp-content\/uploads\/2023\/03\/Protein-Protein-Interaktion-an-einer-Membranschicht-300x170.jpg 300w\" sizes=\"(max-width: 745px) 100vw, 745px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Protein interaction at a membrane layer.<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-88a7fa6 elementor-widget elementor-widget-spacer\" data-id=\"88a7fa6\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-669bd0c elementor-section-boxed elementor-section-gap-beside-yes elementor-section-height-default elementor-section-height-default elementor-section-column-vertical-align-stretch elementor-invisible\" data-id=\"669bd0c\" data-element_type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;unicampFadeInUp&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-extended\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f17e4a3\" data-id=\"f17e4a3\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b0b5504 elementor-widget elementor-widget-tm-heading\" data-id=\"b0b5504\" data-element_type=\"widget\" data-widget_type=\"tm-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"tm-modern-heading\">\n\t\t\t\n\t\t\t\t\t<div class=\"heading-primary-wrap\">\n\t\t\t<h4 class=\"heading-primary elementor-heading-title\">Mediation of protein-protein interactions<\/h4>\t\t<\/div>\n\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bf8c83f elementor-widget elementor-widget-spacer\" data-id=\"bf8c83f\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-0c3f3c0 elementor-section-boxed elementor-section-gap-beside-yes elementor-section-height-default elementor-section-height-default elementor-section-column-vertical-align-stretch\" data-id=\"0c3f3c0\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-extended\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-ced398f\" data-id=\"ced398f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-dc658e3 elementor-widget elementor-widget-text-editor\" data-id=\"dc658e3\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<p>Within the cell the majority of proteins is in permanent exchange with other proteins. We use complex computer simulations to elucidate these associations in atomistic details. We found out that the surrounding water has a pronouncing effect during aggregation. Based on these observations, we now investigate the role of small ligand molecules on such protein-protein interactions, which can either be inhibited or in turn facilitated. This strategy allows to develop new clinical therapies for the treatment of cancer.<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f34571c elementor-hidden-desktop elementor-widget elementor-widget-spacer\" data-id=\"f34571c\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-a604371\" data-id=\"a604371\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8f3ccdb elementor-widget elementor-widget-image\" data-id=\"8f3ccdb\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-image\">\n\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" loading=\"lazy\" width=\"749\" height=\"421\" src=\"https:\/\/zbi-dev.cs.uni-saarland.de\/wp-content\/uploads\/2023\/03\/Bindung-von-XIAP-an-Caspase-3.jpg\" class=\"attachment-full size-full wp-image-6179\" alt=\"\" srcset=\"https:\/\/zbi-dev.cs.uni-saarland.de\/wp-content\/uploads\/2023\/03\/Bindung-von-XIAP-an-Caspase-3.jpg 749w, https:\/\/zbi-dev.cs.uni-saarland.de\/wp-content\/uploads\/2023\/03\/Bindung-von-XIAP-an-Caspase-3-300x169.jpg 300w\" sizes=\"(max-width: 749px) 100vw, 749px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Binding of XIAP protein (grey) to caspase-3 (green).<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>About us The research group headed by Prof. Dr. Helms applies numerical simulations, as well as statistical methods to study biomolecular interactions and control loops in cells. Current topics of interest are the modeling of protein-protein contacts, as well as interactions between DNA and proteins, which both play a central role in the control of all major biological processes. Within the field of membrane bioinformatics, we are deriving structural and functional motifs from the protein sequences of integral membrane proteins. Of particular interest to us is to increase the understanding of specific molecular interactions in the context of large scale biological processes. This affords insights into the origin of diseases at the molecular level. To the group&#8217;s website Section of a gene regulatory network of the bacterium E. coli with annotated mutations in antibiotic resistance genes. Head of the Group Prof. Dr. Volkhard Helms Volkhard Helms has been Professor of Bioinformatics in the Center of Bioinformatics Saar since 2003 and is also a member of the CBI Saar Directorate. He studied physics in Freiburg and Munich and obtained his PhD at the European Molecular Biology Laboratory in Heidelberg in 1996. He then carried out post- doctoral work at the University of California, San Diego, and went on to lead a research group in theoretical biophysics at the Max Planck Institute of Biophysics in Frankfurt. In 2001 he was selected as an EMBO Young Investigator. &#8220;Via the modelling of single biomolecular interactions and regulation processes the group desires to arrive at a comprehensive understanding of cell biological processes.&#8221; Our Projects Functional assignment of transmembrane proteins About a quarter of all proteins is integrated into the cell membrane or into the membranes of cellular compartments. There, they mediate the transport of small molecules through the membrane, or transduct signals from messenger substances, which dock to the cell into its interior. We are particularly interested in elucidating the assignment of substrate molecules to their corresponding membrane transporters, because only little is known so far. For this purpose, we are developing new statistical methods, as well as a software environment to model a virtual cell membrane. Protein interaction at a membrane layer. Mediation of protein-protein interactions Within the cell the majority of proteins is in permanent exchange with other proteins. We use complex computer simulations to elucidate these associations in atomistic details. We found out that the surrounding water has a pronouncing effect during aggregation. Based on these observations, we now investigate the role of small ligand molecules on such protein-protein interactions, which can either be inhibited or in turn facilitated. This strategy allows to develop new clinical therapies for the treatment of cancer. Binding of XIAP protein (grey) to caspase-3 (green).<\/p>\n","protected":false},"author":5,"featured_media":0,"parent":6094,"menu_order":135,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"wf_page_folders":[214],"acf":[],"_links":{"self":[{"href":"https:\/\/zbi-dev.cs.uni-saarland.de\/wp-json\/wp\/v2\/pages\/3668"}],"collection":[{"href":"https:\/\/zbi-dev.cs.uni-saarland.de\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/zbi-dev.cs.uni-saarland.de\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/zbi-dev.cs.uni-saarland.de\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/zbi-dev.cs.uni-saarland.de\/wp-json\/wp\/v2\/comments?post=3668"}],"version-history":[{"count":21,"href":"https:\/\/zbi-dev.cs.uni-saarland.de\/wp-json\/wp\/v2\/pages\/3668\/revisions"}],"predecessor-version":[{"id":6252,"href":"https:\/\/zbi-dev.cs.uni-saarland.de\/wp-json\/wp\/v2\/pages\/3668\/revisions\/6252"}],"up":[{"embeddable":true,"href":"https:\/\/zbi-dev.cs.uni-saarland.de\/wp-json\/wp\/v2\/pages\/6094"}],"wp:attachment":[{"href":"https:\/\/zbi-dev.cs.uni-saarland.de\/wp-json\/wp\/v2\/media?parent=3668"}],"wp:term":[{"taxonomy":"wf_page_folders","embeddable":true,"href":"https:\/\/zbi-dev.cs.uni-saarland.de\/wp-json\/wp\/v2\/wf_page_folders?post=3668"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}