{"id":8031,"date":"2023-04-12T17:32:13","date_gmt":"2023-04-12T15:32:13","guid":{"rendered":"https:\/\/zbi-dev.cs.uni-saarland.de\/?page_id=8031"},"modified":"2023-04-13T22:52:57","modified_gmt":"2023-04-13T20:52:57","slug":"projects","status":"publish","type":"page","link":"https:\/\/zbi-dev.cs.uni-saarland.de\/en\/research-at-the-cbi\/projects\/","title":{"rendered":"Projects"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"8031\" class=\"elementor elementor-8031\">\n\t\t\t\t\t\t<div class=\"elementor-inner\">\n\t\t\t\t<div class=\"elementor-section-wrap\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-fc94d42 elementor-section-boxed elementor-section-gap-beside-yes elementor-section-height-default elementor-section-height-default elementor-section-column-vertical-align-stretch elementor-invisible\" data-id=\"fc94d42\" data-element_type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;unicampFadeInUp&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-extended\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ae1fdcf\" data-id=\"ae1fdcf\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b2853fc elementor-widget elementor-widget-tm-heading\" data-id=\"b2853fc\" data-element_type=\"widget\" data-widget_type=\"tm-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"tm-modern-heading\">\n\t\t\t\n\t\t\t\t\t<div class=\"heading-primary-wrap\">\n\t\t\t<h2 class=\"heading-primary elementor-heading-title\">Overview\u200b<\/h2>\t\t<\/div>\n\t\t\n\t\t\t\t    <div class=\"heading-divider\"><\/div>\n\t    \n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fe77dfc elementor-widget elementor-widget-spacer\" data-id=\"fe77dfc\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.14.0 - 26-06-2023 *\/\n.elementor-column .elementor-spacer-inner{height:var(--spacer-size)}.e-con{--container-widget-width:100%}.e-con-inner>.elementor-widget-spacer,.e-con>.elementor-widget-spacer{width:var(--container-widget-width,var(--spacer-size));--align-self:var(--container-widget-align-self,initial);--flex-shrink:0}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container,.e-con-inner>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer,.e-con>.elementor-widget-spacer>.elementor-widget-container,.e-con>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer{height:100%}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer>.elementor-spacer-inner,.e-con>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer>.elementor-spacer-inner{height:var(--container-widget-height,var(--spacer-size))}<\/style>\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-879c419 elementor-widget elementor-widget-text-editor\" data-id=\"879c419\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.14.0 - 26-06-2023 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<p>The Center for Bioinformatics participates in the\u00a0<a href=\"https:\/\/www.graduateschool-computerscience.de\/\">Graduate School for Computer Science<\/a>\u00a0and the\u00a0<a href=\"https:\/\/www.mmci.uni-saarland.de\/\">Cluster of Excellence (MMCI)<\/a> and plays a central role in many projects, for example:<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-65343e3 elementor-widget elementor-widget-spacer\" data-id=\"65343e3\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-809b2ac elementor-section-gap-beside-no elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-section-column-vertical-align-stretch\" data-id=\"809b2ac\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-extended\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-4938b95\" data-id=\"4938b95\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-96574cb elementor-widget elementor-widget-text-editor\" data-id=\"96574cb\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<ul><li><a href=\"https:\/\/zbi-dev.cs.uni-saarland.de\/en\/research-at-the-cbi\/projects\/?elementor-preview=8031&amp;ver=1681416461#blueprint\">Blueprint<\/a><\/li><li><a href=\"https:\/\/zbi-dev.cs.uni-saarland.de\/en\/research-at-the-cbi\/projects\/?elementor-preview=8031&amp;ver=1681416461#chain\">CHAIN<\/a><\/li><li><a href=\"https:\/\/zbi-dev.cs.uni-saarland.de\/en\/research-at-the-cbi\/projects\/?elementor-preview=8031&amp;ver=1681416461#deep\">DEEP project<\/a><\/li><li><a href=\"https:\/\/gepris.dfg.de\/gepris\/OCTOPUS\/?context=projekt&amp;id=234518095&amp;module=gepris&amp;task=showDetail\">DFG project<\/a><br \/>\u201cInfection Biology and Epidemiology of Staphylococci and Staphylococcal Diseases in sub-Saharan Africa\u201d<\/li><li>BioMarker Detection (supported by Siemens)<\/li><\/ul>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-e4210a7\" data-id=\"e4210a7\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a94b47b elementor-widget elementor-widget-text-editor\" data-id=\"a94b47b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<ul><li><a href=\"https:\/\/zbi-dev.cs.uni-saarland.de\/en\/research-at-the-cbi\/projects\/?elementor-preview=8031&amp;ver=1681416461#dzif\">DZIF (German Center for Infection Research)<\/a><\/li><li><a href=\"https:\/\/zbi-dev.cs.uni-saarland.de\/en\/research-at-the-cbi\/projects\/?elementor-preview=8031&amp;ver=1681416461#graduiertenkolleg\">Graduate School 1276<\/a><br \/>Structure formation and transport in complex systems\u00a0<\/li><li><a href=\"https:\/\/zbi-dev.cs.uni-saarland.de\/en\/research-at-the-cbi\/projects\/?elementor-preview=8031&amp;ver=1681416461#predemics\">PREDEMICS<\/a><\/li><li><a href=\"https:\/\/zbi-dev.cs.uni-saarland.de\/en\/research-at-the-cbi\/projects\/?elementor-preview=8031&amp;ver=1681416461#sfb\">SFB 1027, project C3<\/a><br \/>Stochastic switching during cell differentiation\/reprogramming<\/li><\/ul>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-56557c3 elementor-widget elementor-widget-spacer\" data-id=\"56557c3\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ed22422 elementor-widget elementor-widget-text-editor\" data-id=\"ed22422\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<p>Many more and newer projects are presented in detail on the websites of the respective research groups.<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a43a9e3 elementor-widget elementor-widget-spacer\" data-id=\"a43a9e3\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ce4fff0 elementor-widget elementor-widget-menu-anchor\" data-id=\"ce4fff0\" data-element_type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.14.0 - 26-06-2023 *\/\nbody.elementor-page .elementor-widget-menu-anchor{margin-bottom:0}<\/style>\t\t<div id=\"blueprint\" class=\"elementor-menu-anchor\"><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a9369f8 elementor-widget elementor-widget-premium-addon-button\" data-id=\"a9369f8\" data-element_type=\"widget\" data-widget_type=\"premium-addon-button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\r\n\r\n\t\t<a class=\"premium-button premium-button-none premium-btn-lg premium-button-none\" href=\"https:\/\/zbi-dev.cs.uni-saarland.de\/en\/research-at-the-cbi\/research-groups\/\">\r\n\t\t\t<div class=\"premium-button-text-icon-wrapper\">\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span >\r\n\t\t\t\t\tTo the research groups\t\t\t\t<\/span>\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<i class=\"premium-svg-nodraw premium-drawable-icon icon icon-right-arrow\" aria-hidden=\"true\"><\/i>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t<\/a>\r\n\r\n\r\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ce9b8b5 elementor-widget elementor-widget-spacer\" data-id=\"ce9b8b5\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a78a9bd elementor-section-boxed elementor-section-gap-beside-yes elementor-section-height-default elementor-section-height-default elementor-section-column-vertical-align-stretch elementor-invisible\" data-id=\"a78a9bd\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;animation&quot;:&quot;unicampFadeInUp&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-extended\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7d48e62\" data-id=\"7d48e62\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8ca51aa elementor-widget elementor-widget-spacer\" data-id=\"8ca51aa\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-be5ea89 elementor-widget elementor-widget-tm-heading\" data-id=\"be5ea89\" data-element_type=\"widget\" data-widget_type=\"tm-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"tm-modern-heading\">\n\t\t\t\n\t\t\t\t\t<div class=\"heading-primary-wrap\">\n\t\t\t<h2 class=\"heading-primary elementor-heading-title\">Blueprint<\/h2>\t\t<\/div>\n\t\t\n\t\t\t\t    <div class=\"heading-divider\"><\/div>\n\t    \n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-44d380e elementor-widget elementor-widget-spacer\" data-id=\"44d380e\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a11cb2c elementor-widget elementor-widget-text-editor\" data-id=\"a11cb2c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<p>This largest EU project in the life sciences ever (2011-2016, 40M \u20ac budget, 30M \u20ac EU funding) represents the European contribution to IHEC. The project focuses on the cells and diseases of the blood. J\u00f6rn Walter and Thomas Lengauer are partners in BLUEPRINT covering the topics DNA methylation and software tools and analyzing methylation data as well as intergative analysis of heterogeneous epigenetics data, respectively.<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d78d774 elementor-widget elementor-widget-menu-anchor\" data-id=\"d78d774\" data-element_type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div id=\"chain\" class=\"elementor-menu-anchor\"><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ef81373 elementor-widget elementor-widget-spacer\" data-id=\"ef81373\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-554d80d elementor-widget elementor-widget-premium-addon-button\" data-id=\"554d80d\" data-element_type=\"widget\" data-widget_type=\"premium-addon-button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\r\n\r\n\t\t<a class=\"premium-button premium-button-none premium-btn-lg premium-button-none\" href=\"https:\/\/ihec-epigenomes.org\/research\/projects\/blueprint\/\">\r\n\t\t\t<div class=\"premium-button-text-icon-wrapper\">\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span >\r\n\t\t\t\t\tRead more\t\t\t\t<\/span>\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<i class=\"premium-svg-nodraw premium-drawable-icon icon icon-right-arrow\" aria-hidden=\"true\"><\/i>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t<\/a>\r\n\r\n\r\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-246ce93 elementor-widget elementor-widget-spacer\" data-id=\"246ce93\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-10da99f elementor-section-boxed elementor-section-gap-beside-yes elementor-section-height-default elementor-section-height-default elementor-section-column-vertical-align-stretch elementor-invisible\" data-id=\"10da99f\" data-element_type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;unicampFadeInUp&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-extended\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-9ff7f57\" data-id=\"9ff7f57\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d3e7e8b elementor-widget elementor-widget-spacer\" data-id=\"d3e7e8b\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-25d4f0d elementor-widget elementor-widget-tm-heading\" data-id=\"25d4f0d\" data-element_type=\"widget\" data-widget_type=\"tm-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"tm-modern-heading\">\n\t\t\t\n\t\t\t\t\t<div class=\"heading-primary-wrap\">\n\t\t\t<h2 class=\"heading-primary elementor-heading-title\">CHAIN<\/h2>\t\t<\/div>\n\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4eb0ab7 elementor-widget elementor-widget-tm-heading\" data-id=\"4eb0ab7\" data-element_type=\"widget\" data-widget_type=\"tm-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"tm-modern-heading\">\n\t\t\t\n\t\t\t\t\t<div class=\"heading-primary-wrap\">\n\t\t\t<div class=\"heading-primary elementor-heading-title\">Collaborative HIV and Anti-HIV Drug Resistance Network<\/div>\t\t<\/div>\n\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-285b388 elementor-widget elementor-widget-spacer\" data-id=\"285b388\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fa7f3b3 elementor-widget elementor-widget-text-editor\" data-id=\"fa7f3b3\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<p>This EU Integrating Project (2009-2014) is concerned with bringing advanced HIV resistance analysis technology to the clinic. MPI Informatics (Thomas Lengauer) is partner of the project in their role as partner of the EuResist Consortium. The work in this project partly covers the activities of MPI Informatics in furthering their very successful bioinformatical technology for interpreting clinical and virological data on HIV drug resistance. Several of the software offers on the geno2pheno Server offering the resistance analysis methods for free have<br \/>found entry into clinical practice.<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cd95643 elementor-widget elementor-widget-menu-anchor\" data-id=\"cd95643\" data-element_type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div id=\"deep\" class=\"elementor-menu-anchor\"><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9b1ccd5 elementor-widget elementor-widget-spacer\" data-id=\"9b1ccd5\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8acb1db elementor-widget elementor-widget-premium-addon-button\" data-id=\"8acb1db\" data-element_type=\"widget\" data-widget_type=\"premium-addon-button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\r\n\r\n\t\t<a class=\"premium-button premium-button-none premium-btn-lg premium-button-none\" href=\"https:\/\/www.genafor.org\/services.php\">\r\n\t\t\t<div class=\"premium-button-text-icon-wrapper\">\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span >\r\n\t\t\t\t\tRead more\t\t\t\t<\/span>\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<i class=\"premium-svg-nodraw premium-drawable-icon icon icon-right-arrow\" aria-hidden=\"true\"><\/i>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t<\/a>\r\n\r\n\r\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ca6da7b elementor-widget elementor-widget-spacer\" data-id=\"ca6da7b\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4d81a15 elementor-section-boxed elementor-section-gap-beside-yes elementor-section-height-default elementor-section-height-default elementor-section-column-vertical-align-stretch elementor-invisible\" data-id=\"4d81a15\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;animation&quot;:&quot;unicampFadeInUp&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-extended\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-67af54b\" data-id=\"67af54b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-efc5578 elementor-widget elementor-widget-spacer\" data-id=\"efc5578\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b428607 elementor-widget elementor-widget-tm-heading\" data-id=\"b428607\" data-element_type=\"widget\" data-widget_type=\"tm-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"tm-modern-heading\">\n\t\t\t\n\t\t\t\t\t<div class=\"heading-primary-wrap\">\n\t\t\t<h2 class=\"heading-primary elementor-heading-title\">DEEP<\/h2>\t\t<\/div>\n\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-47f08c3 elementor-widget elementor-widget-tm-heading\" data-id=\"47f08c3\" data-element_type=\"widget\" data-widget_type=\"tm-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"tm-modern-heading\">\n\t\t\t\n\t\t\t\t\t<div class=\"heading-primary-wrap\">\n\t\t\t<div class=\"heading-primary elementor-heading-title\">German Epigenome Program<\/div>\t\t<\/div>\n\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e40f1a2 elementor-widget elementor-widget-spacer\" data-id=\"e40f1a2\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0618494 elementor-widget elementor-widget-text-editor\" data-id=\"0618494\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<p>This five-year prgram (2012-2017) which is being funded by the German Science Minsirty with roughly 20 M\u20ac represents the German contribution to the International Human Epigenome Consoritum (IHEC). The project comprises the measurement and biological interpretation of about 70 reference epigenomes from (mostly) human and mouse. The focus is on metabolic and immunological diseases. The Center provides the coordinator off DEEP (J\u00f6rn Walter, Genetics and Epigenetics, UdS) and the coordinator of the data analysis effort in the project (Thomas Lengauer, MPI Informatics).<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0b7a71d elementor-widget elementor-widget-menu-anchor\" data-id=\"0b7a71d\" data-element_type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div id=\"dzif\" class=\"elementor-menu-anchor\"><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cca8a78 elementor-widget elementor-widget-spacer\" data-id=\"cca8a78\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-176d09a elementor-widget elementor-widget-premium-addon-button\" data-id=\"176d09a\" data-element_type=\"widget\" data-widget_type=\"premium-addon-button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\r\n\r\n\t\t<a class=\"premium-button premium-button-none premium-btn-lg premium-button-none\" href=\"http:\/\/www.deutsches-epigenom-programm.de\/de\/home\/\">\r\n\t\t\t<div class=\"premium-button-text-icon-wrapper\">\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span >\r\n\t\t\t\t\tRead more\t\t\t\t<\/span>\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<i class=\"premium-svg-nodraw premium-drawable-icon icon icon-right-arrow\" aria-hidden=\"true\"><\/i>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t<\/a>\r\n\r\n\r\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d8a7b60 elementor-widget elementor-widget-spacer\" data-id=\"d8a7b60\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-35976b7 elementor-section-boxed elementor-section-gap-beside-yes elementor-section-height-default elementor-section-height-default elementor-section-column-vertical-align-stretch elementor-invisible\" data-id=\"35976b7\" data-element_type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;unicampFadeInUp&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-extended\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6be6374\" data-id=\"6be6374\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a7578ff elementor-widget elementor-widget-spacer\" data-id=\"a7578ff\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0211939 elementor-widget elementor-widget-tm-heading\" data-id=\"0211939\" data-element_type=\"widget\" data-widget_type=\"tm-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"tm-modern-heading\">\n\t\t\t\n\t\t\t\t\t<div class=\"heading-primary-wrap\">\n\t\t\t<h2 class=\"heading-primary elementor-heading-title\">DZIF<\/h2>\t\t<\/div>\n\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b1353e2 elementor-widget elementor-widget-tm-heading\" data-id=\"b1353e2\" data-element_type=\"widget\" data-widget_type=\"tm-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"tm-modern-heading\">\n\t\t\t\n\t\t\t\t\t<div class=\"heading-primary-wrap\">\n\t\t\t<div class=\"heading-primary elementor-heading-title\">German Centre for Infection Research<\/div>\t\t<\/div>\n\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fce26c9 elementor-widget elementor-widget-spacer\" data-id=\"fce26c9\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f0de097 elementor-widget elementor-widget-text-editor\" data-id=\"f0de097\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<p>In this project, the CBI Saar acts as an outpost of the DZIF site Bonn-K\u00f6ln with an own budget. Research at the Bonn-Cologne partner site addresses the following topics:<\/p><ul><li>Infection &amp; immunity research<\/li><li>Anti-microbial effector mechanisms<\/li><li>Translational infectious disease research (target identification, gene therapy, drug research)<\/li><li>Clinical trials and research<\/li><li>Epidemiology of infection and resistance development, infection control<\/li><\/ul>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4d97368 elementor-widget elementor-widget-menu-anchor\" data-id=\"4d97368\" data-element_type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div id=\"graduiertenkolleg\" class=\"elementor-menu-anchor\"><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8e89bc6 elementor-widget elementor-widget-spacer\" data-id=\"8e89bc6\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-979206a elementor-widget elementor-widget-premium-addon-button\" data-id=\"979206a\" data-element_type=\"widget\" data-widget_type=\"premium-addon-button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\r\n\r\n\t\t<a class=\"premium-button premium-button-none premium-btn-lg premium-button-none\" href=\"https:\/\/www.dzif.de\/de\">\r\n\t\t\t<div class=\"premium-button-text-icon-wrapper\">\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span >\r\n\t\t\t\t\tRead more\t\t\t\t<\/span>\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<i class=\"premium-svg-nodraw premium-drawable-icon icon icon-right-arrow\" aria-hidden=\"true\"><\/i>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t<\/a>\r\n\r\n\r\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bf8d0e2 elementor-widget elementor-widget-spacer\" data-id=\"bf8d0e2\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7d21bb0 elementor-section-boxed elementor-section-gap-beside-yes elementor-section-height-default elementor-section-height-default elementor-section-column-vertical-align-stretch elementor-invisible\" data-id=\"7d21bb0\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;animation&quot;:&quot;unicampFadeInUp&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-extended\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-896cdd5\" data-id=\"896cdd5\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-00de0be elementor-widget elementor-widget-spacer\" data-id=\"00de0be\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-638ebfd elementor-widget elementor-widget-tm-heading\" data-id=\"638ebfd\" data-element_type=\"widget\" data-widget_type=\"tm-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"tm-modern-heading\">\n\t\t\t\n\t\t\t\t\t<div class=\"heading-primary-wrap\">\n\t\t\t<h2 class=\"heading-primary elementor-heading-title\">Graduate School 1276<\/h2>\t\t<\/div>\n\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e0e0cb0 elementor-widget elementor-widget-tm-heading\" data-id=\"e0e0cb0\" data-element_type=\"widget\" data-widget_type=\"tm-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"tm-modern-heading\">\n\t\t\t\n\t\t\t\t\t<div class=\"heading-primary-wrap\">\n\t\t\t<div class=\"heading-primary elementor-heading-title\">Structure formation and transport in complex systems<\/div>\t\t<\/div>\n\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-853b180 elementor-widget elementor-widget-spacer\" data-id=\"853b180\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-053090c elementor-widget elementor-widget-text-editor\" data-id=\"053090c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<p>The research group of Prof. Helms uses computer simulations to investigate the dynamics and energetics of single and interacting proteins, as well as their interactions with cell membranes. Besides the usual atomistic molcular dynamics simulations, we develop model systems with medium-resolution potentials. These potentials can either be generated using individual amino acids or even whole proteins. To simulate protein-protein interactions as well as interactions of proteins and membranes, the participants are first modeled as rigid bodies. Subsequently, their Brownian movement subject to external forces is simulated.<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f97af4f elementor-widget elementor-widget-menu-anchor\" data-id=\"f97af4f\" data-element_type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div id=\"predemics\" class=\"elementor-menu-anchor\"><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-357b839 elementor-widget elementor-widget-spacer\" data-id=\"357b839\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-29f65fc elementor-widget elementor-widget-premium-addon-button\" data-id=\"29f65fc\" data-element_type=\"widget\" data-widget_type=\"premium-addon-button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\r\n\r\n\t\t<a class=\"premium-button premium-button-none premium-btn-lg premium-button-none\" href=\"http:\/\/www.uni-saarland.de\/fak7\/graduiertenkolleg\/HomepageGK\/\">\r\n\t\t\t<div class=\"premium-button-text-icon-wrapper\">\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span >\r\n\t\t\t\t\tRead more\t\t\t\t<\/span>\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<i class=\"premium-svg-nodraw premium-drawable-icon icon icon-right-arrow\" aria-hidden=\"true\"><\/i>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t<\/a>\r\n\r\n\r\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c7c70bb elementor-widget elementor-widget-spacer\" data-id=\"c7c70bb\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8a58c65 elementor-section-boxed elementor-section-gap-beside-yes elementor-section-height-default elementor-section-height-default elementor-section-column-vertical-align-stretch elementor-invisible\" data-id=\"8a58c65\" data-element_type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;unicampFadeInUp&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-extended\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-cca44d0\" data-id=\"cca44d0\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-24d478c elementor-widget elementor-widget-spacer\" data-id=\"24d478c\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ffcc5c2 elementor-widget elementor-widget-tm-heading\" data-id=\"ffcc5c2\" data-element_type=\"widget\" data-widget_type=\"tm-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"tm-modern-heading\">\n\t\t\t\n\t\t\t\t\t<div class=\"heading-primary-wrap\">\n\t\t\t<h2 class=\"heading-primary elementor-heading-title\">PREDEMICS<\/h2>\t\t<\/div>\n\t\t\n\t\t\t\t    <div class=\"heading-divider\"><\/div>\n\t    \n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-280cd9e elementor-widget elementor-widget-spacer\" data-id=\"280cd9e\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-89e030b elementor-widget elementor-widget-text-editor\" data-id=\"89e030b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<p>This EU projekt (2011-2016) performs research on four viruses that bear epidemic risk for humanity, namely influenza, rabies virus, flaviviruses and Hepatitis E virus. MPI Informatics (Thomas Lengauer) contributes to the development of software for sharing and analyzing the respective viral sequence data.<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b45d922 elementor-widget elementor-widget-menu-anchor\" data-id=\"b45d922\" data-element_type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div id=\"sfb\" class=\"elementor-menu-anchor\"><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2d0c222 elementor-widget elementor-widget-spacer\" data-id=\"2d0c222\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-284ce76 elementor-widget elementor-widget-premium-addon-button\" data-id=\"284ce76\" data-element_type=\"widget\" data-widget_type=\"premium-addon-button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\r\n\r\n\t\t<a class=\"premium-button premium-button-none premium-btn-lg premium-button-none\" href=\"https:\/\/predemics.biomedtrain.eu\/cms\/default\">\r\n\t\t\t<div class=\"premium-button-text-icon-wrapper\">\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span >\r\n\t\t\t\t\tRead more\t\t\t\t<\/span>\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<i class=\"premium-svg-nodraw premium-drawable-icon icon icon-right-arrow\" aria-hidden=\"true\"><\/i>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t<\/a>\r\n\r\n\r\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-65c8a4c elementor-widget elementor-widget-spacer\" data-id=\"65c8a4c\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b1f7c83 elementor-section-boxed elementor-section-gap-beside-yes elementor-section-height-default elementor-section-height-default elementor-section-column-vertical-align-stretch elementor-invisible\" data-id=\"b1f7c83\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;animation&quot;:&quot;unicampFadeInUp&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-extended\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-093f8cc\" data-id=\"093f8cc\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8645bc7 elementor-widget elementor-widget-spacer\" data-id=\"8645bc7\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8a91c20 elementor-widget elementor-widget-tm-heading\" data-id=\"8a91c20\" data-element_type=\"widget\" data-widget_type=\"tm-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"tm-modern-heading\">\n\t\t\t\n\t\t\t\t\t<div class=\"heading-primary-wrap\">\n\t\t\t<h2 class=\"heading-primary elementor-heading-title\">SFB 1027 - Project C3<\/h2>\t\t<\/div>\n\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1848de2 elementor-widget elementor-widget-tm-heading\" data-id=\"1848de2\" data-element_type=\"widget\" data-widget_type=\"tm-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"tm-modern-heading\">\n\t\t\t\n\t\t\t\t\t<div class=\"heading-primary-wrap\">\n\t\t\t<div class=\"heading-primary elementor-heading-title\">Stochastic switching during cell differentiation\/reprogramming<\/div>\t\t<\/div>\n\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-47290fa elementor-widget elementor-widget-spacer\" data-id=\"47290fa\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b3d16bd elementor-widget elementor-widget-text-editor\" data-id=\"b3d16bd\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<p>Gene expression in all biological cells is tightly regulated by the binding of transcription factors and by epigenetic modifications of the DNA. Importantly, gene expression and cell differentiation or cell reprogramming are triggered by suitable stimuli in a stochastic manner. Here, atomistic biomolecular simulations and coarse-grained Brownian dynamics simulations will be used to study the binding processes governing gene expression in the E.coli pap operon that is being studied experimentally in project C1. A second part of the project involves stochastic dynamics simulations to model state transitions of the gene-regulatory network centered on the pluripotency factors Oct4, Nanog and Sox2. In collaboration with project C2, we will characterize how dynamic changes of transcription factor concentrations and DNA methylation levels affect cell differentiation during the development of the early mouse embryo until the 32-cell stage.<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9b9434d elementor-widget elementor-widget-spacer\" data-id=\"9b9434d\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-187df26 elementor-widget elementor-widget-premium-addon-button\" data-id=\"187df26\" data-element_type=\"widget\" data-widget_type=\"premium-addon-button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\r\n\r\n\t\t<a class=\"premium-button premium-button-none premium-btn-lg premium-button-none\" href=\"https:\/\/www.sfb1027.uni-saarland.de\/\">\r\n\t\t\t<div class=\"premium-button-text-icon-wrapper\">\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span >\r\n\t\t\t\t\tRead more\t\t\t\t<\/span>\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<i class=\"premium-svg-nodraw premium-drawable-icon icon icon-right-arrow\" aria-hidden=\"true\"><\/i>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t<\/a>\r\n\r\n\r\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-42fef98 elementor-widget elementor-widget-spacer\" data-id=\"42fef98\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Overview\u200b The Center for Bioinformatics participates in the\u00a0Graduate School for Computer Science\u00a0and the\u00a0Cluster of Excellence (MMCI) and plays a central role in many projects, for example: Blueprint CHAIN DEEP project DFG project\u201cInfection Biology and Epidemiology of Staphylococci and Staphylococcal Diseases in sub-Saharan Africa\u201d BioMarker Detection (supported by Siemens) DZIF (German Center for Infection Research) Graduate School 1276Structure formation and transport in complex systems\u00a0 PREDEMICS SFB 1027, project C3Stochastic switching during cell differentiation\/reprogramming Many more and newer projects are presented in detail on the websites of the respective research groups. To the research groups Blueprint This largest EU project in the life sciences ever (2011-2016, 40M \u20ac budget, 30M \u20ac EU funding) represents the European contribution to IHEC. The project focuses on the cells and diseases of the blood. J\u00f6rn Walter and Thomas Lengauer are partners in BLUEPRINT covering the topics DNA methylation and software tools and analyzing methylation data as well as intergative analysis of heterogeneous epigenetics data, respectively. Read more CHAIN Collaborative HIV and Anti-HIV Drug Resistance Network This EU Integrating Project (2009-2014) is concerned with bringing advanced HIV resistance analysis technology to the clinic. MPI Informatics (Thomas Lengauer) is partner of the project in their role as partner of the EuResist Consortium. The work in this project partly covers the activities of MPI Informatics in furthering their very successful bioinformatical technology for interpreting clinical and virological data on HIV drug resistance. Several of the software offers on the geno2pheno Server offering the resistance analysis methods for free havefound entry into clinical practice. Read more DEEP German Epigenome Program This five-year prgram (2012-2017) which is being funded by the German Science Minsirty with roughly 20 M\u20ac represents the German contribution to the International Human Epigenome Consoritum (IHEC). The project comprises the measurement and biological interpretation of about 70 reference epigenomes from (mostly) human and mouse. The focus is on metabolic and immunological diseases. The Center provides the coordinator off DEEP (J\u00f6rn Walter, Genetics and Epigenetics, UdS) and the coordinator of the data analysis effort in the project (Thomas Lengauer, MPI Informatics). Read more DZIF German Centre for Infection Research In this project, the CBI Saar acts as an outpost of the DZIF site Bonn-K\u00f6ln with an own budget. Research at the Bonn-Cologne partner site addresses the following topics: Infection &amp; immunity research Anti-microbial effector mechanisms Translational infectious disease research (target identification, gene therapy, drug research) Clinical trials and research Epidemiology of infection and resistance development, infection control Read more Graduate School 1276 Structure formation and transport in complex systems The research group of Prof. Helms uses computer simulations to investigate the dynamics and energetics of single and interacting proteins, as well as their interactions with cell membranes. Besides the usual atomistic molcular dynamics simulations, we develop model systems with medium-resolution potentials. These potentials can either be generated using individual amino acids or even whole proteins. To simulate protein-protein interactions as well as interactions of proteins and membranes, the participants are first modeled as rigid bodies. Subsequently, their Brownian movement subject to external forces is simulated. Read more PREDEMICS This EU projekt (2011-2016) performs research on four viruses that bear epidemic risk for humanity, namely influenza, rabies virus, flaviviruses and Hepatitis E virus. MPI Informatics (Thomas Lengauer) contributes to the development of software for sharing and analyzing the respective viral sequence data. Read more SFB 1027 &#8211; Project C3 Stochastic switching during cell differentiation\/reprogramming Gene expression in all biological cells is tightly regulated by the binding of transcription factors and by epigenetic modifications of the DNA. Importantly, gene expression and cell differentiation or cell reprogramming are triggered by suitable stimuli in a stochastic manner. Here, atomistic biomolecular simulations and coarse-grained Brownian dynamics simulations will be used to study the binding processes governing gene expression in the E.coli pap operon that is being studied experimentally in project C1. A second part of the project involves stochastic dynamics simulations to model state transitions of the gene-regulatory network centered on the pluripotency factors Oct4, Nanog and Sox2. In collaboration with project C2, we will characterize how dynamic changes of transcription factor concentrations and DNA methylation levels affect cell differentiation during the development of the early mouse embryo until the 32-cell stage. Read more<\/p>\n","protected":false},"author":5,"featured_media":0,"parent":8018,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"wf_page_folders":[214],"acf":[],"_links":{"self":[{"href":"https:\/\/zbi-dev.cs.uni-saarland.de\/wp-json\/wp\/v2\/pages\/8031"}],"collection":[{"href":"https:\/\/zbi-dev.cs.uni-saarland.de\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/zbi-dev.cs.uni-saarland.de\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/zbi-dev.cs.uni-saarland.de\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/zbi-dev.cs.uni-saarland.de\/wp-json\/wp\/v2\/comments?post=8031"}],"version-history":[{"count":7,"href":"https:\/\/zbi-dev.cs.uni-saarland.de\/wp-json\/wp\/v2\/pages\/8031\/revisions"}],"predecessor-version":[{"id":8527,"href":"https:\/\/zbi-dev.cs.uni-saarland.de\/wp-json\/wp\/v2\/pages\/8031\/revisions\/8527"}],"up":[{"embeddable":true,"href":"https:\/\/zbi-dev.cs.uni-saarland.de\/wp-json\/wp\/v2\/pages\/8018"}],"wp:attachment":[{"href":"https:\/\/zbi-dev.cs.uni-saarland.de\/wp-json\/wp\/v2\/media?parent=8031"}],"wp:term":[{"taxonomy":"wf_page_folders","embeddable":true,"href":"https:\/\/zbi-dev.cs.uni-saarland.de\/wp-json\/wp\/v2\/wf_page_folders?post=8031"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}