Dr. Tim Kehl – Lenhof Group

2023

[23+HZS] Henn, D., Zhao, Sivarajav, D., Trotsyuk, A., Bonham, C.A., Fischer, K.S., Kehl, T., Fehlmann, T., Greco, A.H., Kussie, H.C., Moortgat Illouz, S.E., Padmanabhan, J., Barrera, J.A., Kneser, U., Lenhof H.-P., Januszyk, M., Levi, B., Keller, A., Longaker M.T., Chen, K., Qi, L.S., Gurtner, G.C. Cas9-mediated knockout of Ndrg2 enhances the regenerative potential of dendritic cells for wound healing. Nature Communications, 2023. DOI: 10.1038/s41467-023-40519-z.

[22+DHK] Diener, C., Hart, M., Kehl, T., Becker-Dorison, A., Tänzer, T., Schub, D., Krammes, L., Sester, M., Keller, A., Unger, M., Walch-Rückheim, B., Lenhof, H.-P., Meese, E. Time-resolved RNA signatures of CD4+ T cells in Parkinson’s disease. Nature Cell Death Discovery, 2023. DOI: 10.1038/s41420-023-01333-0.

2022

[MNS+22] Menegatti, J., Nakel, J.,1, Stepanov, Y.K., Caban, K.M., Ludwig, N., Nord, R., Pfitzner, T., Yazdani, M., Vilimova, M., Kehl, T., Lenhof, H.-P., Philipp, S.E., Meese, E., Fröhlich, T., Grässer, F.A., 1, Hart, M. Changes of Protein Expression after CRISPR/Cas9 Knockout of miRNA-142 in Cell Lines Derived from Diffuse Large B-Cell Lymphoma. Cancers, 2022. DOI: 10.3390/cancers14205031.

[LEG+22] Lenhof, K., Eckhart, L., Gerstner, N., Kehl, T., Lenhof, H.-P. Simultaneous regression and classification for drug sensitivity prediction using an advanced random forest method. Scientific Reports, 2022. DOI: 10.1038/s41598-022-17609-x.

[VKK+22] Vardapour, R., Kehl, T., Kneitz; S., Ludwig, N., Meese, E., Lenhof, H.-P., Gessler, M. The DGCR8 E518K mutation found in Wilms tumors leads to a partial miRNA processing defect that alters gene expression patterns and biological processes, Oxford Academic Carcinogenesis, 2022. DOI: 10.1093/carcin/bgab110.

2021

[GKL+21] Gerstner, N., Kehl, T., Lenhof, K., Eckhart, L., Schneider, L., Stöckel, D., Backes, C., Meese, E., Keller, A., Lenhof, H.-P. GeneTrail: A Framework for the Analysis of High-Throughput Profiles. Frontiers in Molecular Biosciences, 2021. DOI: 10.3389/fmolb.2021.716544.

[LGK+21] Lenhof, K., Gerstner, N., Kehl, T., Eckhart, L., Schneider, L., Lenhof, H.-P. MERIDA: a novel Boolean logic-based integer linear program for personalized cancer therapy. Bioinformatics, btab 546, 2021. DOI: 10.1093/bioinformatics/btab546.

[KPL+21] Kern, F., Aparicio-Puerta, E., Li, Y., Fehlmann, T., Kehl, T., Wagner, V., Ray K., Ludwig N., Lenhof, H.-P., Meese, E., Keller A. miRTargetLink 2.0—interactive miRNA target gene and target pathway networks. Nucleic Acids Research, 2021. DOI: org/10.1093/nar/gkab297.

[KKD+21] Kern, F., Krammes, L., Danz, K., Diener, C., Kehl, T., Küchler, O., Fehlmann, T., Kahraman, M., Rheinheimer, S., Aparicio-Puerta, E., Wagner, S., Ludwig, N., Backes, C., Lenhof, H.-P., von Briesen, H., Hart, M., Keller, A., Meese, E. Validation of human microRNA target pathways enables evaluation of target prediction tools. Nucleic Acids Research, 2021. DOI: 10.1093/nar/gkaa1161.

2020

[HNW-R20] Hart, M., Nickl, L., Walch-Rueckheim, B., Krammes, L., Rheinheimer, S., Diener, C.,Taenzer, T., Kehl, T., Sester, M., Lenhof, H.-P., Keller, A., Meese, E. Wrinkle in the plan: miR-34a-5p impacts chemokine signaling by modulating CXCL10/CXCL11/CXCR3-axis in CD4+, CD8+ T cells, and M1 macrophages. Journal for ImmunoTherapy of Cancer, 2020. DOI: 10.1136/jitc-2020-001617.

[DHK+20] Diener, C., Hart, M., Kehl, T., Rheinheimer, S., Ludwig, N.,Krammes, L., Pawusch, S., Lenhof, K., Tänzer, T., Schub, D., Sester, M., Walch-Rückheim,B., Keller, A., Lenhof, H.-P., Meese, E. Quantitative and time-resolved miRNA pattern of early human T cell activation. Nucleic Acids Research, 2020. DOI: 10.1093/nar/gkaa788.

[GKL+20] Gerstner, N., Kehl, T., Lenhof, K., Müller, A., Mayer, C., Eckhart, L., Grammes, N.L., Diener, C., Hart, M., Hahn, O., Walter, J., Wyss-Coray, T., Meese, E., Keller, A., Lenhof, H.-P. GeneTrail 3: advanced high-throughput enrichment analysis. Nucleic Acids Research, 2020. DOI:10.1093/nar/gkaa306.

2019

[KKB+19] Kehl, T., Kern, F., Backes, C., Fehlmann, T., Stöckel, D., Meese, E., Lenhof, H.-P., Keller, A. miRPathDB 2.0: a novel release of the miRNA Pathway Dictionary Database. Nucleic Acids Research, Dezember 2019. DOI: 10.1093/nar/gkz1022.

[HWK+19] Hart, M., Walch-Rückheim, B., Krammes, K., Kehl, T., Rheinheimer, S., Tänzer, T., Glombitza, B., Sester, M., Lenhof, H.-P., Keller, A., Meese, E. miR-34a as hub of T cell regulation networks. Journal for Immunotherapy of Cancer 7 (1), 187, 2019. DOI: 10.1186/s40425-019-0670-5.

[SKT+19] Schneider, L., Kehl, T., Thedinga, K., Grammes, N. L., Backes, C., Mohr, C., Schubert, B., Lenhof, K., Gerstner, N., Hartkopf. A. D., Wallwiener, M., Kohlbacher, O., Keller, A., Meese, E., Graf, N., Lenhof, H.-P. ClinOmicsTrail bc: a visual analytics tool for breast cancer treatment stratification, Bioinformatics, btz302, 2019. DOI: 10.1093/bioinformatics/btz302.

[KSK+19] Kehl, T., Schneider, L., Kattler, K., Stöckel, D., Wegert, J., Gerstner, N., Ludwig, N., Distler, U., Tenzer, S., Gessler, M., Walter, J., Keller, A., Graf, N., Meese, E., Lenhof, H.-P. The role of TCF3 as potential master regulator in blastemal Wilms tumors. International Journal of Cancer 144 (6), 1432-1443, 2019. DOI: 10.1002/ijc.31834.

[FLB+19] Fehlmann, T., Laufer, T., Backes, C., Kahramann, M., Alles, J., Fischer, U., Minet, M., Ludwig, N., Kern, F., Kehl, T., Galata, V., Düsterloh, A., Schrörs, H., Kohlhaas, J., Bals, R., Huwer, H., Geffers, L., Krüger, R., Balling, B., Lenhof, H.-P., Meese, E., Keller, A. Large-scale validation of miRNAs by disease association, evolutionary conservation and pathway activity. RNA Biology 16 (1), 93-103, 2019. DOI: 10.1080/15476286.2018.1559689.

2018

[KSK+18] Kehl, T., Schneider, L., Kattler, K., Stöckel, D., Wegert, J., Gerstner, N., Ludwig, N., Distler, U., Schick, M., Keller, U., Tenzer, S., Gessler, M., Walter, J., Keller, A., Graf, N., Meese, E., Lenhof, H.-P. REGGAE: a novel approach for the identification of key transcriptional regulators. Bioinformatics. Bioinformatics 34 (20), 3503-3510, 2018. DOI: 10.1093/bioinformatics/bty372.

2017

[BKS+17] Backes C., Kehl T., Stöckel D., Fehlmann T., Schneider L., Meese E., Lenhof H.-P., Keller A. miRPathDB: a new dictionary on microRNAs and target pathways. Nucleic Acids Res. 2017 Jan 4;45(D1):D90-D96. doi: 10.1093/nar/gkw926

[KBK+17] Kehl, T., Backes, C., Kern, F., Fehlmann, T., Ludwig, N., Meese, E., Lenhof, H.-P., Keller, A. About miRNAs, miRNA seeds, target genes and target pathways. Oncotarget 8 (63), 107167, 2017. DOI: 10.18632/oncotarget.22363.

[BFK+17] Backes, C., Fehlmann, T., Kern, F., Kehl, T., Lenhof, H.-P., Meese, E., Keller, A. miRCarta: a central repository for collecting miRNA candidates. Nucleic Acids Research 46 (D1), D160-D167, 2017. DOI: 10.1093/nar/gkx851.

[KSS+17] Kehl, T., Schneider, L., Schmidt, F., Stöckel, D., Gerstne,r N., Backes, C., Meese, E., Keller, A., Schulz, M.H., Lenhof, H.-P. RegulatorTrail: a web service for the identification of key transcriptional regulators. Nucleic Acids Research 45 (W1), W146-W153, 2017. DOI: 10.1093/nar/gkx350.

2016

[SSK+16] Schneider, L., Stöckel, D., Kehl, T., Gerasch, A., Ludwig, N., Leidinger, P., Huwer, H., Tenzer, S., Kohlbacher, O., Hildebrandt, A., Kaufmann, M., Gessler, M., Keller, A., Meese, E., Graf, N., and Lenhof, H.-P.: DrugTargetInspector: An assistance tool for patient treatment stratification. Int J Cancer. 2016 Apr 1;138(7):1765-76. doi: 10.1002/ijc.29897.

[SKT+16] Stöckel, D., Kehl, T., Trampert, P., Schneider, L., Backes, C., Ludwig, N., Gerasch, A., Kaufmann, M., Gessler, M., Graf, N., Meese, E., Keller, A., Lenhof, H.P.,: Multi-omics Enrichment Analysis using the GeneTrail2 Web Service. Bioinformatics 2016; doi: 10.1093/bioinformatics/btv770

2013

[SMK+13] Stöckel, D., Müller, O., Kehl, T., Gerasch, A., Backes, C., Rurainski, A., Keller, A., Kaufmann, M., and Lenhof, H.-P.: NetworkTrail - A web service for identifying and visualizing deregulated subnetworks. Bioinformatics 29 (13):1702-03, 2013.