Dr. Tim Kehl
July 7, 2015 2023-11-10 11:17Dr. Tim Kehl
Researcher
My name is Tim Kehl and I am a researcher at the chair of Prof. Dr. Hans-Peter Lenhof. We are developing new algorithms, tools and databases for the analysis of human pathologies, especially cancer. In particular, I am interested in the analysis of deregulated biological processes and the identification of molecular factors that drive those processes.
Contact
Center for Bioinformatics
Saarland Informatics Campus
Saarland University
Building E2.1, Room 414
P.O. Box 15 11 50
66041 Saarbrücken
Germany
Research
- Cancer research
- Enrichment analysis
- miRNAs
- Network analysis
- Regulatory genomics
- Systems biology
Education
- M.Sc. Computational Molecular Biology / Bioinformatics, Saarland University, May 2015
- B.Sc. Computational Molecular Biology / Bioinformatics, Saarland University, June 2013
Teaching
- Bioinformatics I : WS15/16, WS16/17, WS17/18, WS18/19, WS19/20, WS20/21, WS21/22
- Bioinformatics II : SS15, SS16, SS17, SS18, SS19, SS20, SS21
- Effizientes Lernen : WS15/16, WS16/17, WS17/18, WS18/19, WS19/20, WS20/21, WS21/22
- Proseminar “Bioinformatic Approaches for Cancer Research” : SS15
- Proseminar “Bioinformatic Approaches for Personalized Cancer Treatment” : WS15/16, SS16, WS16/17, SS17, WS17/18, SS18, WS18/19, SS19, WS19/20
- Proseminar “Bioinformatic Approaches for Regulatory Genomics” : SS18, WS18/19
- Proseminar “Pathway and Network Analysis in Cancer Research”: WS16/17, SS17
- Proseminar “Computational Biomarker Discovery”: SS20, WS20/21, SS21, WS21/22
- Seminar “Computational Systems Biology of Cancer” : WS16/17, SS17, WS17/18, SS18, WS18/19, SS19, WS19/20
- Seminar “Inferring Network Structure from Data” : SS15
- Seminar “Machine Learning” : SS18
- Seminar “Probabilistic graphical models in disease” : WS15/16, SS16
- Seminar “Novel Methods for Modeling Gene Regulation”: SS19, WS19/20, SS20, WS20/21
- Seminar “Bioinformatics Approaches for Single Cell Analysis”: SS20, WS20/21, SS21
- Seminar “Machine Learning Applications in Bioinformatics”: SS21, WS21/22
Latest Publications
[23+HZS] Henn, D., Zhao, Sivarajav, D., Trotsyuk, A., Bonham, C.A., Fischer, K.S., Kehl, T., Fehlmann, T., Greco, A.H., Kussie, H.C., Moortgat Illouz, S.E., Padmanabhan, J., Barrera, J.A., Kneser, U., Lenhof H.-P., Januszyk, M., Levi, B., Keller, A., Longaker M.T., Chen, K., Qi, L.S., Gurtner, G.C. Cas9-mediated knockout of Ndrg2 enhances the regenerative potential of dendritic cells for wound healing. Nature Communications, 2023. DOI: 10.1038/s41467-023-40519-z.
[22+DHK] Diener, C., Hart, M., Kehl, T., Becker-Dorison, A., Tänzer, T., Schub, D., Krammes, L., Sester, M., Keller, A., Unger, M., Walch-Rückheim, B., Lenhof, H.-P., Meese, E. Time-resolved RNA signatures of CD4+ T cells in Parkinson’s disease. Nature Cell Death Discovery, 2023. DOI: 10.1038/s41420-023-01333-0.
[MNS+22] Menegatti, J., Nakel, J.,1, Stepanov, Y.K., Caban, K.M., Ludwig, N., Nord, R., Pfitzner, T., Yazdani, M., Vilimova, M., Kehl, T., Lenhof, H.-P., Philipp, S.E., Meese, E., Fröhlich, T., Grässer, F.A., 1, Hart, M. Changes of Protein Expression after CRISPR/Cas9 Knockout of miRNA-142 in Cell Lines Derived from Diffuse Large B-Cell Lymphoma. Cancers, 2022. DOI: 10.3390/cancers14205031.
[LEG+22] Lenhof, K., Eckhart, L., Gerstner, N., Kehl, T., Lenhof, H.-P. Simultaneous regression and classification for drug sensitivity prediction using an advanced random forest method. Scientific Reports, 2022. DOI: 10.1038/s41598-022-17609-x.
[VKK+22] Vardapour, R., Kehl, T., Kneitz; S., Ludwig, N., Meese, E., Lenhof, H.-P., Gessler, M. The DGCR8 E518K mutation found in Wilms tumors leads to a partial miRNA processing defect that alters gene expression patterns and biological processes, Oxford Academic Carcinogenesis, 2022. DOI: 10.1093/carcin/bgab110.