Research
January 18, 2012 2023-11-15 16:03Research
Our research group develops bioinformatics methods and software for the elucidation of pathogenic processes and for the diagnosis, prognosis, and therapy of diseases.
Former Projects
Here, we present a list of our former projects. Please visit the given links for more information about the respective projects.
BALL
The Biochemical Algorithms Library (BALL) is a C++ framework for rapid software prototyping in Computational Molecular Biology and Molecular Modeling.
BN++
The Biochemical Network library (BN++) is a comprehensive framework for modeling, analyzing, and visualizing biochemical pathways and networks.
CAP
The 'Cancer-Associated Proteins' database (CAP) is an integrated tool for analysing proteins that show an altered expression in certain tumor types.
Docking
The main goal of this project is the development of algorithms for predicting the 3D-structures of protein-protein complexes.
DTI
DrugTargetInspector is an interactive assitance tool for patient treatment stratification.
GeneTrail
We are developing a web-based application, called GeneTrail, that facilitates the statistical evaluation of comprehensive genomic and proteomic data sets with respect to the enrichment of biological categories.
Molecular Diagnosis
Sets of autologous antigen possess high potential for non invasive molecular diagnosis and monitoring. We are developing a statistical framework to perform an accurate diagnosis of various diseases based on autoantibody profiles.
Solvation
Since most biochemical processes require the presence of water, solvation effects play a major role that have to be modelled correctly in order to achieved reliable and meaningful binding energy and docking predictions. Therefore, we are developing improved continuum models for solvation.