Since 2005 the UdS research groups of Prof. Keller, Prof. Lenhof, and Prof. Meese developed and published more than 30 novel approaches for the diagnosis and prognosis of diseases, e.g., for Alzheimer disease, different types of cancers, COPD, Multiples sclerosis, etc. Most of the approaches are based on antigen or miRNA pattern and apply machine learning methods (ML, AI).